Urografin¶

Overview¶

Field	Detail
Drug class	Ionic contrast media
Route	IV
Stock vial	Urografin 150 (150 mg I/mL) or Urografin 370 (370 mg I/mL)
Reconstituted conc.	N/A (Ready to use)
Diluent	Nil
Storage	Room temp; Protect from light and X-rays

Note

Similar to other contrast agents. See also Omnipaque, Visipaque, Ultravist.

Preparation¶

Before you start

Check the expiry date and vial integrity before opening. Label every syringe immediately after drawing up — never leave unlabelled syringes on the tray. Confirm the iodine concentration on the vial label (150 mg I/mL or 370 mg I/mL).

Equipment needed¶

1 × Urografin vial (150 mg I/mL or 370 mg I/mL)
Normal saline (NS) — for IDT dilutions
1 mL syringes × 4 (for test doses/dilutions)
25 G needles

Step 1 — Prepare the SPT solution (neat)¶

Draw up 0.5–1 mL of the stock into a 1 mL syringe.
Label: "Urografin SPT [concentration]" (e.g. "Urografin SPT 370 mg I/mL").

Step 2 — Prepare IDT dilutions¶

Prepare in this order, using a fresh syringe for each step.

IDT 1
- Draw 0.1 mL of stock into a 1 mL syringe. Add 0.9 mL NS. Mix. (This is 1:10).
- Draw 0.1 mL of this 1:10 into a new 1 mL syringe. Add 0.9 mL NS. Mix. (This is 1:100).
- Label: "Urografin IDT 1:100".
IDT 1:10:
- Draw 0.1 mL of stock into a 1 mL syringe. Add 0.9 mL NS. Mix. (This is 1:10).
- Label: "Urografin IDT 1:10".
IDT 1:10 (500 U/mL):
- Draw up a fresh 0.5 mL of stock into a 1 mL syringe.
- Label: "Urografin IDT Neat".

Skin prick test (SPT)¶

Reagent	Concentration
Test solution	Neat
Positive control	Histamine 10 mg/mL
Negative control	Normal saline

Interpretation: Wheal ≥3 mm vs negative control = positive.

Intradermal test (IDT)¶

Dilution series¶

Step	Dilution	Concentration	Preparation
1	1:100	—	0.1 mL of 1:10 + 0.9 mL NS
2	1:10	—	0.1 mL neat + 0.9 mL NS
3	Neat	500 U/mL	Undiluted stock

Inject: 0.05 mL intradermal. Read at 15–20 minutes. Delayed Reading: If history is suggestive of a delayed reaction, re-read at 24 and 48 hours.