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Ethinylestradiol / Levonorgestrel (Microgynon 20 ED)

Overview

Field Detail
Drug class Hormonal contraceptive
Route Oral
Stock vial Ethinylestradiol 20 µg / Levonorgestrel 100 µg tablet
Reconstituted conc. Crush tablet, dissolve in NS for testing
Diluent Nil
Storage Room temp; Protect from light and moisture

Note

SPT only — no IDT protocol available for this drug. Tablets must be crushed and dissolved in normal saline to prepare the SPT test solution.

Preparation

Before you start

Check the expiry date and blister pack integrity before opening. Label every syringe immediately after drawing up — never leave unlabelled syringes on the tray.

Equipment needed

  • 1 × Microgynon 20 ED tablet (Ethinylestradiol 20 µg / Levonorgestrel 100 µg)
  • Mortar and pestle (for crushing tablet)
  • Normal saline (NS) 0.9% — for dissolving crushed tablet
  • 1 mL syringe × 1
  • 25 G needles

Step 1 — Prepare the SPT solution (neat — crushed tablet solution)

  1. Place one Microgynon 20 ED tablet into a clean mortar.
  2. Crush the tablet to a fine powder using the pestle.
  3. Add a small volume of NS (approximately 1–2 drops) to the powder and mix to form a paste/solution.
  4. Draw up the solution into a 1 mL syringe.
  5. Label: "Microgynon 20 ED SPT (crushed tablet solution)".

Skin prick test (SPT)

Reagent Concentration
Test solution Neat (crushed tablet solution)
Positive control Histamine 10 mg/mL
Negative control Normal saline

Interpretation: Wheal ≥3 mm vs negative control = positive.