Esomeprazole (Nexium)¶
Overview¶
| Field | Detail |
|---|---|
| Drug class | Proton Pump Inhibitor (PPI) |
| Formulation | 20 mg tablets / capsules |
| Stock concentration | 20 mg/mL (reconstituted for testing) |
| Storage | Room temp |
Preparation¶
Testing Method
PPI testing is typically performed via Oral Graded Challenge (OGC). Skin testing (SPT) with reconstituted oral formulations (Neat) may be performed but has limited validated sensitivity.
Equipment needed¶
- 1 × Esomeprazole 20 mg tablet/capsule
- Water for swallowing
- Observation chart
Oral Graded Challenge (OGC)¶
| Step | Dose | Formulation | Cumulative Dose |
|---|---|---|---|
| 1 | 2 mg | 1/10 Tablet (or liquid equiv) | 2 mg |
| 2 | 20 mg | 1 Tablet | 22 mg |
Interval: 60 minutes between steps.
Skin prick test (SPT)¶
| Reagent | Concentration |
|---|---|
| Test solution | Neat (20 mg/mL) |
| Positive control | Histamine 10 mg/mL |
| Negative control | Normal saline |
Preparation: Dissolve 20 mg in 1 mL NS. Use the supernatant for SPT. Interpretation: Wheal ≥3 mm vs negative control = positive.