Clindamycin (Dalacin)¶
Overview¶
| Field | Detail |
|---|---|
| Drug class | Lincosamide antibiotic |
| Stock vial | 600 mg/4 mL (150 mg/mL) or 300 mg/2 mL (150 mg/mL) |
| Reconstituted conc. | N/A (Ready to use) |
| Storage | Room temp; Do not refrigerate |
Preparation¶
Before you start
Ensure the vial contains 150 mg/mL. Check expiry and integrity. Note that this is a concentrated formulation.
Equipment needed¶
- 1 × Clindamycin 150 mg/mL vial
- Normal saline (NS) — for IDT dilutions
- 1 mL syringes × 2
- 25 G needles
Step 1 — Prepare the SPT solution (150 mg/mL — neat)¶
- Draw up 0.5–1 mL of the stock (150 mg/mL) into a 1 mL syringe.
- Label: "Clindamycin SPT 150 mg/mL".
Step 2 — Prepare IDT dilutions¶
Prepare in this order, using a fresh syringe for each step.
- IDT 15 mg/mL (1:10):
- Draw 0.1 mL of stock (150 mg/mL) into a 1 mL syringe. Add 0.9 mL NS. Mix. (This is 15 mg/mL — 1:10).
- Label: "Clindamycin IDT 15 mg/mL".
Skin prick test (SPT)¶
| Reagent | Concentration |
|---|---|
| Test solution | Neat (150 mg/mL) |
| Positive control | Histamine 10 mg/mL |
| Negative control | Normal saline |
Interpretation: Wheal ≥3 mm vs negative control = positive.
Intradermal test (IDT)¶
Dilution series¶
| Step | Dilution | Concentration | Preparation |
|---|---|---|---|
| 1 | 1:10 | 15 mg/mL | 0.1 mL neat + 0.9 mL NS |
Inject: 0.05 mL intradermal. Read at 15–20 minutes. Delayed Reading: If history is suggestive of a delayed reaction, re-read at 24 and 48 hours.